Chemicals can cause
cancer, and workers handling them should learn the safety rules as a means of
primary prevention. Historically, it is interesting that one of the first
chemically induced cancers to be noticed by doctors was in chimney sweeps whose
contact with the tarry material in the chimneys led to cancers of the scrotum.
Chromate chemicals today can cause lung cancer; aniline dyes can cause bladder
cancer; asbestos can lead to cancers of the outer lining of the lungs or the
intestinal cavity. Some 500 chemicals have been found to cause cancers in
experimental animals. One of these, which were widely used as an artificial
sweetener, cyclamate, was restricted after animal experiments produced cancers
and led to fear that humans using it in large quantities over long periods
might develop cancer.
An additional reason for prevention of chronic liverdisease (page 611) is the tendency of this disease to allow cancer to be
superimposed. Patients with ulcerative colitis need careful scrutiny because of
their higher risk of developing cancer of the diseased colon. Secondary
Prevention Once cancer is found, much can be done to prevent it from becoming a
fatal illness. As we have indicated, cancer can be a curable disease. When the
doctor discovers a lump in a breast or sees a suspicious sore on a lip, he must
make a definitive diagnosis.
Usually this is possible only through removal of part or all
of the suspicious area-biopsy- so a pathologist can examine it microscopically
as well as grossly. If the diagnosis is cancer, then the physician considers
the outlook for the patient in terms of localization versus metastasis or
spread. If there has been spreading, the outlook is much less hopeful than if
the cancer is still confined to the area of origin. For example, a breastcancer which has not spread to lymph nodes in the arm- pit offers a 70 percent
or better chance for cure.
If there has been a single metastasis, the chance
for cure may drop to 50 percent. If there have been several metastases, the
likelihood of living five years may drop to about 25 percent. Similarly, for
example, a kidney cancer that has spread to a bone has a much more ominous
outlook than one that is still confined to the kidney.
With metastasis, treatment usually depends upon radiation and
chemicals, often less likely to provide permanent cure than when a surgeon can
remove an entire intact growth at its primary site. Thus, early detection is
the key to effective secondary prevention in cancer. Cancer in early stages
rarely makes its presence known by such general symptoms as fever or loss of
weight. It does, however, often provide local signals such as a painless lump
in the breast or bleeding in stomach or rectum.
Cardinal signs of cancer are
lumps or sores that do not heal; bleeding from any part of the body when there
is no obvious explanation for the bleeding; chronic hoarseness; chronic cough;
unexplained stomach or intestinal symptoms such as constipation, diarrhea,
nausea, vomiting, "indigestion"; unexplained pain; jaundice; impaired
vision; convulsions; possibly headache.
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