How drugs Interacts with our body mechanism? And Outdated Medicines

OUTDATED MEDICINES

 If your physician has prescribed a drug for you and instructs you to discontinue its use before the supply is all gone don't save what is left over for another time. Discard it. It may seem like a waste to throw away expensive medication; actually, it is an important safety precaution. Some drugs lose potency with time; some gain potency. Either way, their use after a lapse of time can be dangerous.

 Moreover, it has become clear that some drugs, in the process of aging, not only change in potency; they undergo marked chemical changes that can make them dangerous. Not long ago, for example, physicians at three New York hospitals reported on several patients who had suddenly experienced nausea and vomiting and then developed symptoms like those of diabetes. The trouble in each case was traced to chemical deterioration of an antibiotic, a tetracycline, taken long after it should have been thrown away.

DRUG INTERACTIONS 

when one medication is being used, the addition of another sometimes can be helpful but sometimes can be harmful. When two agents used in concert do not harmonize, the interaction or interference can cause trouble. Moreover, even effects on dosage requirements must be considered when two or more medicines are being used. Recently, for example, a patient who had had a heart attack and recovered from it was released from the hospital. 

Ten days later, an alarming condition developed. While in the hospital the patient had received an anticoagulant medication as part of treatment-a compound aimed at preventing clotting. At home, he continued as directed to take the same compound in the same dosage. But now the drug was thinning.

 The blood too much

 Something had changed. It had indeed: in the hospital, the patient had been given phenobarbital upon retiring. The sedative, in the course of its activity in the body, had stimulated certain liver chemicals which broke down the anticoagulant faster. At home, without the phenobarbital, the anticoagulant activity continued longer and was more potent. In effect, without the sedative, the patient was getting an overdose of.

The anti-coagulant

The matter, once understood, was quickly adjusted. But it illustrates what is coming to be virtually a new science in medicine, concerned with understanding and taking into account inter- actions between medicines. This, of course, is not the place to go into complex technical details. 

But as indications of how important interaction can be, here are some recent findings: When a patient is taking aspirin, addition of an anticoagulant drug may lead to bleeding. If a patient is receiving a medication such as amitriptyline for mental depression and is also given guanethidine for high blood pressure, the antihypertensive activity of the latter is lost.