How drugs Interacts with our body mechanism? And Outdated Medicines

OUTDATED MEDICINES

 If your physician has prescribed a drug for you and instructs you to discontinue its use before the supply is all gone don't save what is left over for another time. Discard it. It may seem like a waste to throw away expensive medication; actually, it is an important safety precaution. Some drugs lose potency with time; some gain potency. Either way, their use after a lapse of time can be dangerous.

 Moreover, it has become clear that some drugs, in the process of aging, not only change in potency; they undergo marked chemical changes that can make them dangerous. Not long ago, for example, physicians at three New York hospitals reported on several patients who had suddenly experienced nausea and vomiting and then developed symptoms like those of diabetes. The trouble in each case was traced to chemical deterioration of an antibiotic, a tetracycline, taken long after it should have been thrown away.

DRUG INTERACTIONS 

when one medication is being used, the addition of another sometimes can be helpful but sometimes can be harmful. When two agents used in concert do not harmonize, the interaction or interference can cause trouble. Moreover, even effects on dosage requirements must be considered when two or more medicines are being used. Recently, for example, a patient who had had a heart attack and recovered from it was released from the hospital. 

Ten days later, an alarming condition developed. While in the hospital the patient had received an anticoagulant medication as part of treatment-a compound aimed at preventing clotting. At home, he continued as directed to take the same compound in the same dosage. But now the drug was thinning.

 The blood too much

 Something had changed. It had indeed: in the hospital, the patient had been given phenobarbital upon retiring. The sedative, in the course of its activity in the body, had stimulated certain liver chemicals which broke down the anticoagulant faster. At home, without the phenobarbital, the anticoagulant activity continued longer and was more potent. In effect, without the sedative, the patient was getting an overdose of.

The anti-coagulant

The matter, once understood, was quickly adjusted. But it illustrates what is coming to be virtually a new science in medicine, concerned with understanding and taking into account inter- actions between medicines. This, of course, is not the place to go into complex technical details. 

But as indications of how important interaction can be, here are some recent findings: When a patient is taking aspirin, addition of an anticoagulant drug may lead to bleeding. If a patient is receiving a medication such as amitriptyline for mental depression and is also given guanethidine for high blood pressure, the antihypertensive activity of the latter is lost. 

Administering Drugs with care - Preventive adverse and side effects

First read the label when you take the drug container from the medicine cabinet; read it again when you take the drug itself; and finally, read the label a third time when you put the container away. That last reading is an extra check to make certain you read the label properly the first two times. If you did happen to make a mistake, you have a chance to do something about it at once.

  

TRICKS FOR PROPER DOSAGE made by machines that produce attractive roundedness

 For the most part, are more attractive-looking and less expensive than those that were made individually by a druggist to a special prescription of a physician. The trouble with machine-made articles of medicine, as with mass- produced clothes, is that tailoring to each individual's needs cannot be built in. Thus, it's known that the amount of medicine required varies almost directly with the weight of a person.

Most machine-made capsules and pills are made for a standard person of about 150 pounds so they are apt to contain just a bit too much for most women, a bit too little for most men. Doctors have learned how to adjust dosages even with the limitations of machine-made medicines. For example, consider pills of phenobarbital often prescribed for nervousness, tension, headaches with a psychogenic component. Phenobarbital is commonly available in 1/8, 1/4, and 1/2 grain sizes. Suppose phenobarbital in 1/4 grain dosage is prescribed for a woman and it helps her tension but makes her just a bit too forgetful and drowsy to do her work properly.

The doctor tries 1/8 grain, but that doesn't help her tension enough. The solution lies in going back to the 1/4 grain dosage and proper use of a fingernail file. The patient is instructed to consider a tablet as a circle, and to gently file away one fourth of the circle, to get a tablet that is just halfway between 1/8 and 1/4 grain sizes. 

Usually, the patient "plays around" a bit and finds just the right tailor made size for her needs. When it comes to capsules-especially of sleeping medicines such as Nembutal, Seconal, and Amy talit's a help to learn how to take apart a capsule gently and pour out a portion to adjust the dosage to individual needs, then rejoin the capsule.

 Many people find a standard 1-1/2 grain capsule ineffective; on the other hand, when they take two capsules, they may experience hangovers. One full capsule and half of another may be the right dosage. 

Human body reactions to Medicines and Foods Vs Medicines

REACTIONS TO MEDICINES

It may seem unbelievable but there are more than 250 diseases that can be caused by the very medicines designed to treat and cure illness. You may well ask, "Why is this possible?" The reasons are not difficult to understand. Over the past twenty-five years or so, many hundreds of new com- pounds have been developed for treating and preventing disease. Many are powerful and complicated substances.

Their very effectiveness depends upon their great potency and complexity. In some instances, trouble has come unexpectedly because a powerful A Special Word about medicine taking new agents was not tested fully under every conceivable circumstance. Thus, for example, thalidomide seemed to be an excellent and harmless tranquilizing agent in most people, but when it was used by pregnant women it had terrible effects on their unborn children. Another reason for drug-induced illness is that human beings do have tendencies to develop allergic or sensitivity responses. These vary considerably, just as they do for foods. One person may eat eggs until the hens scream for mercy-and enjoy them with impunity; another person, allergic to them, cannot eat one without developing some upset.

And so with other foods

Because of sensitivity problems, a medicine that is highly beneficial for 95 percent of the population may cause trouble, even potentially serious trouble, for the remaining 5 percent. A good example is penicillin, clearly a lifesaving drug. It has, indeed, probably saved well over a million lives since its discovery. But it also has caused severe sensitivity re- actions in scores of thousands of people and has taken the lives of thousands.

As you may have noticed, physicians today inquire carefully about possible previous sensitivity reactions to penicillin before administering or prescribing it. Just as some people, after repeated exposure, become allergic to rag- weed pollen or to poison ivy, so some, after being helped once or even several times by an antibiotic, may develop allergic reactions to the com- pound. Usually the problem is mild-skin rash, hives, or slight fever- and disappears once the drug is stopped. Occasionally, however, there are anaphylactic, or shock like, reactions which are life-threatening, and these can be overcome only if heroic measures-adrenaline and other injections-are used in time.

Still considered the single most valuable antibiotic,penicillin is a major allergy producer because it has been so widely used. It is estimated that 10 percent of Americans have become sensitized to the drug. Still another reason for undesirable reactions is that no drug is 100 percent specific-hitting the bull's-eye, so to speak. In the course of countering the problem for which it is being used, it may produce other effects, and these have to be reckoned with. Consider, for example, the gastrointestinal upsets-cramps, diarrhea, sore mouth, rectal itch-which may occur after use of many antibiotics.

They can come about because of an upset in the natural germbalance in the body. Many harmless bacteria are always present in the gastrointestinal tract. Some, in fact, are essential to digestion; some manufacture vitamins. When a potent antibiotic is introduced to fight infection, it may also decimate this normal bacterial population. Moreover, these friendly bacteria serve another purpose in the body.

Modern medicines and Health Issues

Modern medicines serve a purpose and very often can provide relief for minor problems. In themselves, they are generally safe as long as the dosage recommendations on the package are not exceeded. It's important to keep in mind, however, that such medications, as any others, may produce undesirable effects in relatively small numbers of people who happen to be particularly sensitive to them.

So if you notice any such side effects as rash, nausea, dizziness, visual disturbances, or others, which seem to follow use of a particular medication, you may well have sensitivity to that particular medication, and no matter how popular it is with other people, it is not for you. If in doubt, you should check with your physician. Absolutely vital when you prescribe for yourself is the need to keep in mind that you may be making a mistake in diagnosis, treating the wrong illness, or masking minor and superficial symptoms while an underlying serious problem gets worse.

For example, a "simple" head cold may really not be simple when there is fever, sharp pain in the chest, sputum discoloration, rapid breathing, or nausea; it may, in fact, be a serious bronchial infection or pneumonia. If you do treat yourself, never continue to do so for more than a day or two unless you are certain there is steady improvement-and if your symptoms get worse or change, don't wait even that long before consulting your physician. 

How taking body temperature helps to prevent certain diseases?

FEVER

Fever most commonly signals infection or inflammation somewhere in the body. The temperature is likely to be highest during a bacterial or severe viral infection. With a mild infection such as a cold, temperature elevation may be slight and fleeting. When fever is high, there is usually no hesitancy about calling the physician. But there may be other occasions when the physician should be consulted.

First

A few facts about taking temperature

Aspirin and aspirin-containing medications bring down elevated temperature and tend to keep it down for as long as four hours. So for accurate determinations, temperature should be taken before use of such medications or four or five hours afterward. Remember, too, that if temperature is taken immediately after smoking, it may be higher than normal; and conversely, if taken by mouth just after a cold drink, it may be lower than normal. Before taking temperature, rinse the thermometer in cool water and shake it until the mercury falls below the 95-degree mark. If you use an oralthermometer, hold it under the tongue, with mouth shut, for at least three minutes.

A rectal thermometer, after lubrication, should be inserted up to the 98.6-degree line while the patient lies on his side. It should remain in place for three to five minutes. For the average person, mouth temperature normally is 98.6 degrees, and rectal tends to be about one degree higher. When fever is mild-under 100 degrees orally or 101 rectally-and the only other symptom is nasal congestion, a slight cough, or a scratchy throat, there is no urgency about calling the physician. But take the temperature every three or four hours and note the severity of symptoms. If symptoms become worse or if the temperature moves up to 101 orally or 102 rectally, then notify your physician. Always when fever is present it is important to note the accompanying.

How Blood Pressure Determination helps to find and Prevent diseases?

 

Measuring blood pressure is an even more important part of the medical check today than it was in the past. For one thing, we know now how common elevated pressure is, affecting at least 17 million Americans. For another thing, we know now that high blood pressure, or hypertension, is an important factor in stroke, heart disease, and kidney disease. And best of all, hypertension today almost invariably can be controlled. Blood pressure is simply the push of blood against the walls of the arteries. It is highest when the heart contracts and pumps blood into the arteries and this peak pressure is called systolic. It is lowest when the heart relaxes between beats, and this lower pressure is the diastolic.

To measure pressure, a basically simple, though not simply named, device, the sphygmomanometer, is used. It's an inflatable cuff attached to mercury or other type of meter. When the cuff is wrapped around the arm above the elbow and inflated, the inflation does two things: it drives the mercury column up to near the top of the gauge and it compresses an artery in the arm so no blood flows through. With his stethoscope placed on the artery, the physician listens as he gradually lets air out of the cuff. At some point, as the air is released, the pressure of blood in the artery will begin to exceed the pressure of air in the cuff, and the blood will begin to flow again in the artery.

The beginning of flow produces a thudding sound the physician can hear through the stethoscope, and at this point the mercury gauge shows what the systolic pressure is. Then, as more air is released from the cuff there comes a point when the thudding sound no longer can be heard, and at this point the mercury gauge shows the diastolic pressure. It is normal for pressure to vary somewhat from day to day, even minute to minute. It goes up with excitement, which is why in an examination a physician may wish to take your pressure several times. In some people, however, the blood pressure is nearly always higher than it should be. 

Heart Attack And Other Problems - Percussion Examination

PERCUSSION

Percussion-a simple procedure to Know heart problems in which the physician lays one hand flat on the chest and raps on it with fingers of the other hand-can provide useful information about some internal organs. With it, the approximate size and shape of the heart may be established, for example. The chest is largely occupied by the lungs which, because they are filled with air, produce a hollow sound when the chest wall above them is tapped. 

Over the heart, which is filled with fluid, the sound has changes to a dull note. The physician can begin percussion at a point on the chest known to be over the lungs, moving in the direction of the heart until a dull sound tells him he has reached it. That establishes one point of the heart's position. Other points can be determined by starting the percussion else- where on the chest and moving in toward the heart again. 

Heart Attack and other Issues in Heart are well explained in the following posts, Please follow all the posts to know about the heart and the problems arising. In this modern days pollution and Global Warming create many issues and the human body cannot tolerate the modern day diseases. Though EBOLA is not a heart related virus directly, We could avoid EBOLA if we were followed some principles and hygienic procedures in Our life. In the same way we can avoid heart issues by adopting certain methods and exercises to avoid the issues in Heart. 

Please follow your physician's instructions in the matters and any suggestion given given here is subject to verify your physician.